Rahul Sharma (Editor)

Parathyroid hormone 2 receptor

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Species
  
Human

Entrez
  
5746

Human
  
Mouse

Ensembl
  
ENSG00000144407

Parathyroid hormone 2 receptor

Aliases
  
PTH2R, PTHR2, parathyroid hormone 2 receptor

External IDs
  
MGI: 2180917 HomoloGene: 3701 GeneCards: PTH2R

Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene

Function

The protein encoded by this gene is a member of the G protein-coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas.

The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues, Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding

References

Parathyroid hormone 2 receptor Wikipedia