Padilla is a Spanish surname. Notable people with the surname include:
Aaron Padilla (artist) (born 1974), American artist and art educatorAarón Padilla (born 1977), Mexican footballerAlejandro García Padilla, Governor of Puerto RicoAnthony Padilla, American comedian and actor and member of the group SmoshAriel López Padilla (born 1962), Mexican actorBela Padilla, Filipino actressBlanca Padilla Spanish fashion ModelCarlos Padilla Velásquez (1932–2014), Honduran footballer and managerCraig Padilla, American ambient musician and film score composer, actor, and video producerDaniel Padilla, Filipino actorDavid Padilla (1927–2016), former president of BoliviaErnesto Padilla (born 1972), Cuban-American artist and cigarmakerFrederick M. Padilla (born 1959), 15th president of the National Defense UniversityHeberto Padilla (1932–2000), Cuban poetIgnacio Padilla (1968–2016), Mexican writerJesús Padilla Gálvez, Spanish philosopherJim Padilla, former Chief Operating Officer of FordJosé Padilla (Sánchez) (1889–1960), Spanish composerJosé Padilla (prisoner) (born 1970), U.S. citizen held as enemy combatant and later convicted of having aided terroristsJosé Prudencio Padilla (1784–1828), Colombian military leaderJuan Gutiérrez de Padilla (c.1590–1664), Mexican composerKylie Padilla, Filipino actressRobin Padilla, Filipino actorRustom Padilla, birth name of BB Gandanghari, Filipino transgender actress and modelMartín de Padilla y Manrique, 1st Count of Santa GadeaMaligiaq Padilla (born 1982), Greenlandic kayakerNathaniel Padilla, Filipino sports shooterVicente Padilla, Major League Baseball pitcher for the Boston Red Sox