Padilla is a Spanish surname. Notable people with the surname include:
Aaron Padilla (artist) (born 1974), American artist and art educator
Aarón Padilla (born 1977), Mexican footballer
Alejandro García Padilla, Governor of Puerto Rico
Anthony Padilla, American comedian and actor and member of the group Smosh
Ariel López Padilla (born 1962), Mexican actor
Bela Padilla, Filipino actress
Blanca Padilla Spanish fashion Model
Carlos Padilla Velásquez (1932–2014), Honduran footballer and manager
Craig Padilla, American ambient musician and film score composer, actor, and video producer
Daniel Padilla, Filipino actor
David Padilla (1927–2016), former president of Bolivia
Ernesto Padilla (born 1972), Cuban-American artist and cigarmaker
Frederick M. Padilla (born 1959), 15th president of the National Defense University
Heberto Padilla (1932–2000), Cuban poet
Ignacio Padilla (1968–2016), Mexican writer
Jesús Padilla Gálvez, Spanish philosopher
Jim Padilla, former Chief Operating Officer of Ford
José Padilla (Sánchez) (1889–1960), Spanish composer
José Padilla (prisoner) (born 1970), U.S. citizen held as enemy combatant and later convicted of having aided terrorists
José Prudencio Padilla (1784–1828), Colombian military leader
Juan Gutiérrez de Padilla (c.1590–1664), Mexican composer
Kylie Padilla, Filipino actress
Robin Padilla, Filipino actor
Rustom Padilla, birth name of BB Gandanghari, Filipino transgender actress and model
Martín de Padilla y Manrique, 1st Count of Santa Gadea
Maligiaq Padilla (born 1982), Greenlandic kayaker
Nathaniel Padilla, Filipino sports shooter
Vicente Padilla, Major League Baseball pitcher for the Boston Red Sox
