Species Human Entrez 29108 | Human Mouse Ensembl ENSG00000103490 | |
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Aliases PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing External IDs MGI: 1931465 HomoloGene: 8307 GeneCards: PYCARD | ||
Template:Structure of full length ASC NMR structure of full length ASC (PDB ID 2KN6)
Contents
NMR structure of full-length ASC: PDB ID 2KN6 [1]
Apoptosis-associated speck-like protein containing a CARD or ASC is a protein that in humans is encoded by the PYCARD gene.
Function
This gene encodes an adaptor protein that is composed of two protein–protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
Interactions
PYCARD has been shown to interact with MEFV.