Entrez 284119 | Ensembl ENSG00000177469 | |
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Aliases PTRF, CAVIN, CAVIN1, CGL4, cavin-1, FKSG13, polymerase I and transcript release factor External IDs MGI: 1277968 HomoloGene: 7499 GeneCards: PTRF | ||
Polymerase I and transcript release factor, also known as PTRF, is a protein which in humans is encoded by the PTRF gene.
Contents
Function
Termination of RNA polymerase I catalyzed transcription is a 2-step process that involves pausing of transcription elongation and release of both the pre-ribosomal RNA and Pol I from the DNA template. The pausing is mediated by TTF1 and PTRF.
PTRF is a soluble protein containing putative leucine zipper, nuclear localization signal, and PEST domains.
Interactions
PTRF has been shown to interact with ZNF148.
References
PTRF Wikipedia(Text) CC BY-SA