Species Human Entrez 5753 | Human Mouse Ensembl ENSG00000101213 | |
 | ||
Aliases PTK6, BRK, protein tyrosine kinase 6 External IDs MGI: 99683 HomoloGene: 68494 GeneCards: PTK6 | ||
Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.
Contents
Function
Tyrosine-protein kinase 6 (also known as Breast Tumor Kinase, Brk) is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.
Clinical significance
Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.
Interactions
PTK6 has been shown to interact with STAP2 and KHDRBS1.
References
PTK6 Wikipedia(Text) CC BY-SA