Entrez 57580 | Ensembl ENSG00000124126 | |
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Aliases PREX1, P-REX1, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 External IDs MGI: 3040696 HomoloGene: 10821 GeneCards: PREX1 | ||
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein is a protein that in humans is encoded by the PREX1 gene.
Contents
Function
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.
Clinical significance
The protein has been implicated in the spread of melanoma skin cancer.
References
PREX1 Wikipedia(Text) CC BY-SA