Species Human Entrez 7799 | Human Mouse Ensembl ENSG00000116731 | |
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Aliases PRDM2, HUMHOXY1, KMT8, MTB-ZF, RIZ, RIZ1, RIZ2, PR domain 2 External IDs MGI: 107628 HomoloGene: 40822 GeneCards: PRDM2 | ||
PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.
Contents
Function
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.
Interactions
PRDM2 has been shown to interact with Estrogen receptor alpha and Retinoblastoma protein.