Species Human Entrez 23532 | Human Mouse Ensembl n/a | |
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Aliases PRAME, CT130, MAPE, OIP-4, OIP4, preferentially expressed antigen in melanoma External IDs HomoloGene: 48404 GeneCards: PRAME | ||
Gene music using protein sequence of prame preferentially expressed antigen in melanoma
Melanoma antigen preferentially expressed in tumors is a protein that in humans is encoded by the PRAME gene.
Contents
Function
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Model organisms
Model organisms have been used in the study of PRAME function. A conditional knockout mouse line called Prametm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping
