Harman Patil (Editor)

PPP2R1A

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Species
  
Entrez
  
5518

Human
  
Ensembl
  
ENSG00000105568

PPP2R1A httpsuploadwikimediaorgwikipediacommonsthu

Aliases
  
PPP2R1A, PP2A-Aalpha, PP2AAALPHA, PR65A, MRD36, protein phosphatase 2 scaffold subunit Aalpha

External IDs
  
MGI: 1926334 HomoloGene: 68559 GeneCards: PPP2R1A

Gene music using protein sequence of ppp2r1a protein phosphatase 2 regulatory subunit a alpha


Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).

Contents

Function

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.

Interactions

PPP2R1A has been shown to interact with:

Arabidopsis RCN1

RCN1 At1g25490 is one of three genes in Arabidopsis encoding Phosphoprotein Phosphatase 2A Regulatory Subunit A (PP2Aa). The association of different b subunits with a PP2Aa-PP2ac dimer is believed to determine substrate specificity.

References

PPP2R1A Wikipedia


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