Entrez 5511 | Ensembl ENSG00000117751 | |
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Aliases PPP1R8, ARD-1, ARD1, NIPP-1, NIPP1, PRO2047, protein phosphatase 1 regulatory subunit 8 External IDs MGI: 2140494 HomoloGene: 8555 GeneCards: PPP1R8 |
Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.
Interactions
PPP1R8 has been shown to interact with PPP1CA, Histone deacetylase 2, SF3B1 and EED.
References
PPP1R8 Wikipedia(Text) CC BY-SA