Species Human Entrez 5495 | Human Mouse Ensembl ENSG00000138032 | |
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Aliases PPM1B, PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX, protein phosphatase, Mg2+/Mn2+ dependent 1B External IDs MGI: 101841 HomoloGene: 2027 GeneCards: PPM1B | ||
Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene.
Contents
Function
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.
Interactions
PPM1B has been shown to interact with:
References
PPM1B Wikipedia(Text) CC BY-SA