Kalpana Kalpana (Editor)

PPM1B

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Species
  
Human

Entrez
  
5495

Human
  
Mouse

Ensembl
  
ENSG00000138032

PPM1B

Aliases
  
PPM1B, PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX, protein phosphatase, Mg2+/Mn2+ dependent 1B

External IDs
  
MGI: 101841 HomoloGene: 2027 GeneCards: PPM1B

Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene.

Contents

Function

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.

Interactions

PPM1B has been shown to interact with:

  • CDK2,
  • CDK6,
  • CHUK,
  • IKBKG,
  • IKK2,
  • MAP3K7, and
  • PPARγ.

    • References

    PPM1B Wikipedia
    (Text) CC BY-SA


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