Species Human Entrez 5420 | Human Mouse Ensembl ENSG00000128567 | |
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Aliases PODXL, Gp200, PC, PCLP, PCLP-1, podocalyxin like External IDs HomoloGene: 136790 GeneCards: PODXL | ||
Podocalyxin-like protein 1 is a protein that in humans is encoded by the PODXL gene.
Contents
Function
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.
Interactions
PODXL has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.