Species Human Entrez 5330 | Human Mouse Ensembl ENSG00000137841 | |
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Aliases PLCB2, PLC-beta-2, phospholipase C beta 2 External IDs MGI: 107465 HomoloGene: 20957 GeneCards: PLCB2 | ||
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.
Contents
Function
The gene codes for the enzyme phospholipase C β2. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.
Interactions
PLCB2 has been shown to interact with MAP2K3 and TRPM7.
References
PLCB2 Wikipedia(Text) CC BY-SA