Samiksha Jaiswal (Editor)

PIAS1

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Species
  
Human

Entrez
  
8554

Human
  
Mouse

Ensembl
  
ENSG00000033800

PIAS1

Aliases
  
PIAS1, DDXBP1, GBP, GU/RH-II, ZMIZ3, protein inhibitor of activated STAT 1

External IDs
  
MGI: 1913125 HomoloGene: 22953 GeneCards: PIAS1

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.

Contents

Function

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.

Interactions

PIAS1 has been shown to interact with:

  • DNMT3A,
  • P53,
  • STAT1,
  • Small ubiquitin-related modifier 1,
  • Sp3 transcription factor, and
  • UBE2I.

    • References

    PIAS1 Wikipedia
    (Text) CC BY-SA