Suvarna Garge (Editor)

PEA15

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Species
  
Human

Entrez
  
8682

Human
  
Mouse

Ensembl
  
ENSG00000162734

PEA15

Aliases
  
PEA15, HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, phosphoprotein enriched in astrocytes 15

External IDs
  
MGI: 104799 HomoloGene: 7884 GeneCards: PEA15

Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.

PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.

PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner.

Interactions

PEA15 has been shown to interact with:

  • Caspase 8,
  • FADD, and
  • MAPK1,
  • Phospholipase D1, and
  • RPS6KA3.
  • References

    PEA15 Wikipedia