Puneet Varma (Editor)

PDE4A

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Species
  
Human

Entrez
  
5141

Human
  
Mouse

Ensembl
  
ENSG00000065989

PDE4A

Aliases
  
PDE4A, DPDE2, PDE4, PDE46, phosphodiesterase 4A

External IDs
  
MGI: 99558 HomoloGene: 4520 GeneCards: PDE4A

cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene.

Contents

Function

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Recently, it has been shown through the use of PDE4A knock out mice that PDE4A may play a role in the regulation of anxiety and emotional memory.

Clinical significance

PDE4A is a target of a number of drugs including:

  • rolipram (antidepressant and antiinflammatory) and cilomilast (antiinflammatory) – inhibits PDE4A isoforms 1, 2, 6, and 7
  • roflumilast (antiinflammatory) – inhibits PDE4A isoforms 1, 2, and 6

    • References

    PDE4A Wikipedia
    (Text) CC BY-SA