Species Human Entrez 10846 | Human Mouse Ensembl ENSG00000112541 | |
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Aliases PDE10A, HSPDE10A19, ADSD2, IOLOD, phosphodiesterase 10A, LINC00473 External IDs MGI: 1345143 HomoloGene: 4852 GeneCards: PDE10A | ||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene.
Contents
Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.
Inhibitors
Research
Preliminary evidence indicates a possible link between PDE10A expression and obesity in mice and humans.
References
PDE10A Wikipedia(Text) CC BY-SA