Entrez 27250 | Ensembl ENSG00000150593 | |
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Aliases PDCD4, H731, programmed cell death 4 (neoplastic transformation inhibitor) External IDs MGI: 107490 HomoloGene: 7879 GeneCards: PDCD4 | ||
Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene. It is one of the targets of an oncomiR, MIRN21.
Contents
Function
This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.
Interactions
PDCD4 has been shown to interact with RPS13 and Ribosomal protein L5.
References
PDCD4 Wikipedia(Text) CC BY-SA