Species Human Entrez 5089 | Human Mouse Ensembl n/a | |
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Aliases PBX2, G17, HOX12, PBX2MHC, PBX homeobox 2 External IDs MGI: 1341793 HomoloGene: 48115 GeneCards: PBX2 | ||
Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.
Contents
Function
This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.
Interactions
PBX2 has been shown to interact with HOXA9.
References
PBX2 Wikipedia(Text) CC BY-SA