Symbol PASTA InterPro IPR005543 PROSITE PDOC51178 | Pfam PF03793 SMART PASTA SCOP 1rp5 | |
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The PASTA domain is a small protein domain that can bind to beta-lactam rings found in antibiotics. The domain was initially discovered in 2002 by Yeats and colleagues as a region of sequence similarity found in penicillin binding proteins and PknB-like kinases found in some bacteria. The name is an acronym derived from PBP and Serine/Threonine kinase Associated domain.
Contents
Structure
The PASTA domain adopts a structure composed of an alpha-helix followed by three beta strands. Recent structural studies show that the extracellular region of PknB that is composed of four PASTA domains shows a linear arrangement of the domains.
Species distribution
PASTA domains are found in a variety of bacterial species including gram-positive firmicutes and actinobacteria.
References
PASTA domain Wikipedia(Text) CC BY-SA