Routes of
administration Oral CAS Number 60607-34-3 CAS ID 60607-34-3 | ATC code R06AE06 (WHO) Molar mass 426.553 g/mol | |
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Trade names Tinset, Cedlips, Atoxan AHFS/Drugs.com International Drug Names Legal status In general: ℞ (Prescription only) | ||
How to pronounce oxatomide
Oxatomide (R35443) is a first-generation antihistamine of the diphenylmethylpiperazine (benzhydrylpiperazine) class. It was discovered at Janssen Pharmaceutica in 1975. Oxatomide lacks any anticholinergic effects. In addition to its H1 receptor antagonism, it also possesses antiserotonergic actions.
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Synthesis
Reaction of 2-Benzimidazolinone with isopropenyl acetate leads to the singly protected imidazolone derivative (2). Alkylation of this with 3-chloro-1-bromopropane affords the functionalized derivative (3). Alkylation of the monobenzhydryl derivative of piperazine (4) with 3 gives oxatomide (5), after hydrolytic removal of the protecting group.
References
Oxatomide Wikipedia(Text) CC BY-SA