Symbol Omptin Pfam clan CL0193 MEROPS A26 | Pfam PF01278 PROSITE PDOC00657 SCOP 1i78 | |
Omptins (EC 3.4.23.49, protease VII, protease A, gene ompT proteins, ompT protease, protein a, Pla, OmpT) are a family of bacterial proteases. They are aspartate proteases, which cleave peptides with the use of a water molecule. Found in the outer membrane of gram-negative enterobacteria such as Shigella flexneri, Yersinia pestis, Escherichia coli, and Salmonella enterica. Omptins consist of a widely conserved beta barrel spanning the membrane with 5 extra-cellular loops. These loops are responsible for the various substrate specificities. These proteases rely upon binding of lipopolysaccharide for activity.
Omptins have been linked with pathogenesis in several bacteria.
References
Omptin Wikipedia(Text) CC BY-SA