Entrez 123264 | Ensembl ENSG00000186198 | |
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Aliases SLC51B, OSTB, OSTBETA, OSTbeta, solute carrier family 51 beta subunit External IDs MGI: 3582052 HomoloGene: 18721 GeneCards: SLC51B | ||
Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.
Function
OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes. The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake. The heterodimer furthermore is essential for intestinal bile acid transport.
OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.
References
OSTbeta Wikipedia(Text) CC BY-SA