Entrez 200931 | Ensembl ENSG00000163959 | |
Aliases SLC51A, OSTA, OSTalpha, solute carrier family 51 alpha subunit External IDs MGI: 2146634 HomoloGene: 44941 GeneCards: SLC51A | ||
Organic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the OSTA gene.
Function
OST-alpha together with OST-beta is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes. The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake. The heterodimer furthermore is essential for intestinal bile acid transport.
OST-alpha and OST-alpha have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.
References
OSTalpha Wikipedia(Text) CC BY-SA