Entrez 26031 | Ensembl ENSG00000070882 | |
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External IDs MGI: 1918970 HomoloGene: 49422 GeneCards: OSBPL3 | ||
Oxysterol-binding protein-related protein 3 is a protein that in humans is encoded by the OSBPL3 gene.
Contents
Function
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Several transcript variants encoding different isoforms have been identified.
Model organisms
Model organisms have been used in the study of OSBPL3 function. A conditional knockout mouse line called Osbpl3tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping