Species Human Entrez 5000 | Human Mouse Ensembl ENSG00000115947 | |
 | ||
Aliases ORC4, ORC4L, ORC4P, origin recognition complex subunit 4 External IDs MGI: 1347043 HomoloGene: 8059 GeneCards: ORC4 | ||
Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.
Contents
Function
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported.
Interactions
ORC4 has been shown to interact with:
References
ORC4 Wikipedia(Text) CC BY-SA