Species Human Entrez 4998 | Human Mouse Ensembl ENSG00000085840 | |
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Aliases ORC1, HSORC1L, PARC1, origin recognition complex subunit 1 External IDs MGI: 1328337 HomoloGene: 31221 GeneCards: ORC1 | ||
Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene.
Contents
Function
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of the pre-replication complex, which includes additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the origin recognition complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MYST2/HBO1), a protein involved in control of transcription silencing.
Interactions
ORC1 has been shown to interact with: