Species Human Entrez 8590 | Human Mouse Ensembl ENSG00000184933 | |
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Aliases OR6A2, I7, OR11-55, OR6A1, OR6A2P, olfactory receptor family 6 subfamily A member 2 External IDs MGI: 97432 HomoloGene: 2743 GeneCards: OR6A2 | ||
Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene.
Contents
Function
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
Clinical significance
Variation in the OR6A2 gene has been identified as a likely cause of some people's strong dislike of coriander (also known as cilantro), often associating it with a combination of soap and vomit, while for others it is closer to the foul smelling odor emitted by stinkbugs. This is due to the presence of aldehyde chemicals, which are present in soap, various detergents, coriander, several species of stinkbugs and cinnamon.