O'Brian is an Irish surname and may refer to:
O'Brian White (born 1985), Jamaican footballer
O'Brian Woodbine (born 1988), Jamaican footballer
Conor O'Brian (born 1980), a ring name of American professional wrestler Ryan Parmeter
Hugh O'Brian (1925-2016), stage name of American actor Hugh Krampe
Jack O'Brian (1914–2000), columnist and supporter of Joseph McCarthy
Patrick O'Brian (1914–2000), pen name of British novelist and translator Richard Russ
Peter O'Brian (film producer) (born 1947), Canadian film producer
Peter O'Brian (actor) (born 1956), New Zealand/Indonesian actor
Chloe O'Brian, a character in the American TV series 24
Morris O'Brian, a character in the American TV series 24
Clive R. O'Brian, a character from the Resident Evil franchise
Olivia O'Brian, a singer
O'Brian Wikipedia (Text) CC BY-SA