EC number 3.6.1.9 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9032-64-8 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a nucleotide diphosphatase (EC 3.6.1.9) is an enzyme that catalyzes the chemical reaction
a dinucleotide + H2OThus, the two substrates of this enzyme are dinucleotide and H2O, whereas its product is mononucleotide.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dinucleotide nucleotidohydrolase. Other names in common use include nucleotide pyrophosphatase, and nucleotide-sugar pyrophosphatase. This enzyme participates in 5 metabolic pathways: purine metabolism, starch and sucrose metabolism, riboflavin metabolism, nicotinate and nicotinamide metabolism, and pantothenate and coa biosynthesis.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1NQY, 1NQZ, 2GSN, 2GSO, and 2GSU.