Now or Never may refer to:

Film and television
Now or Never (1921 film), a 1921 silent film starring Harold Lloyd
Now or Never (1979 film), featuring Tally Brown
Now or Never (2003 film), a comedy-drama film written and directed by Lucio Pellegrini
"Now or Never" (Grey's Anatomy), an episode of Grey's Anatomy
Now or Never, a British morning show in the ITV Day programming block
Now or Never (Tela album), 1998
Now or Never (Nick Carter album), 2002
Now or Never (Blazin' Squad album), 2003
Now or Never (CNBLUE EP), 2009
Now or Never (Tank album), 2010
Now or Never (Bananarama EP), 2012
Now or Never (Mumzy Stranger mix-tape), 2015
Now or Never, an album by John Schneider, 1981
"Now or Never" (Billie Holiday song), 1949
"Now or Never" (Yoko Ono song), 1973
"Now or Never" (Mark Medlock song), written and produced by Dieter Bohlen, 2007
"Now or Never" (High School Musical song), the opening musical number from the film High School Musical 3: Senior Year, 2008
"Now or Never" (Jodie Connor song), featuring vocals by British grime artist Wiley, 2011
"Now or Never" (Outasight song), 2012
"Now or Never" (Halsey song), 2017
"Now or Never", a song by Confide from Recover, 2010
"Now or Never", a song by Dope from Life, 2001
"Now or Never", a song by Everlife from Everlife, 2007
"Now or Never", a song by Godsmack from their eponymous album, 1998
"Now or Never", a song by Josh Groban from Awake, 2006
"Now or Never", a song by Madina Lake from From Them, Through Us, to You, 2007
"Now or Never", a song by Three Days Grace and is the fourth single from Three Days Grace, 2003
"Now or Never", a song by Zebrahead from Playmate of the Year, 2000
"Now or Never", a song by Kendrick Lamar from Good Kid, M.A.A.D City, 2012
"Now or Never", a song by South Korean band CNBLUE, 2009
"Now or Never", a song by Grim Reaper from See You in Hell, 1984
"Now or Never", a song by Tritonal featuring vocals by Phoebe Ryan, 2013
"Now or Never", a song by Halsey, 2017
"Now or Never; Are We to Live or Perish Forever?" or the Pakistan Declaration, a pamphlet by Choudhary Rahmat Ali
"Now or Never" (radio show), a Canadian radio documentary series broadcast on CBC Radio One