ATC code None PubChem CID 114976 Formula C25H35NO4 Molar mass 413.55 g/mol ChemSpider ID 102911 | CAS Number 78715-23-8 ECHA InfoCard 100.208.387 3D model (Jmol) Interactive image Pubchem 114976 | |
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Norbuprenorphine is a major active metabolite of the opioid modulator buprenorphine. It is a μ-opioid, δ-opioid, and nociceptin receptor full agonist, and a κ-opioid receptor partial agonist. In rats, unlike buprenorphine, norbuprenorphine produces marked respiratory depression but with very little antinociceptive effect. In explanation of these properties, norbuprenorphine has been found to be a high affinity P-glycoprotein substrate, and in accordance, shows very limited blood-brain-barrier penetration.
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Norbuprenorphine Wikipedia(Text) CC BY-SA