Non specific polyamine oxidase

Non-specific polyamine oxidase (EC 1.5.3.17, polyamine oxidase, Fms1, AtPAO3) is an enzyme with systematic name polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming). This enzyme catalyses the following chemical reaction

(1) spermine + O₂ + H₂O ⇌ spermidine + 3-aminopropanal + H₂O₂(2) spermidine + O₂ + H₂O ⇌ putrescine + 3-aminopropanal + H₂O₂(3) N¹-acetylspermine + O₂ + H₂O ⇌ spermidine + 3-acetamidopropanal + H₂O₂(4) N¹-acetylspermidine + O₂ + H₂O ⇌ putrescine + 3-acetamidopropanal + H₂O₂

This enzyme is flavoprotein (FAD).