Known for BioModels Database | ||
Born 12 March 1969 (age 48) ( 1969-03-12 ) Fields Computational biologyBioinformaticsNeuroscienceSystems biology Alma maters École Normale Supérieure, Pierre-and-Marie-Curie University, University of Paris-Sud Institutions | ||
Nicolas le nov re describing the whole life cycle of modelling in neuroscience 2010
Nicolas Le Novère is a British and French biologist, senior group leader at the Babraham Institute. His research is focused on modeling signaling pathways and developing tools to share mathematical models.
Contents
- Nicolas le nov re describing the whole life cycle of modelling in neuroscience 2010
- Education
- Research
- References
Education
Le Novère obtained his Baccalauréat at the Prytanée National Militaire. He received a MSc (1993) in Biology and Biochemistry from the École Normale Supérieure, a BSc in Cellular Biology and Physiology (1991), and a PhD in Molecular and Cellular Pharmacology (1998) from the Pierre and Marie Curie University. From 1999 to 2001, he was a Postdoctoral Fellow at the University of Cambridge (UK).
Research
The first part of Le Novère's career, in the laboratory of Jean-Pierre Changeux at the Pasteur Institute, was focused on studying Nicotinic acetylcholine receptors in the brain. He reconstructed their phylogeny, predicted and modeled their structure. He also investigated the role of the alpha6 subunit in the dopaminergic neurons of the mesencephalon.
During his post-doctoral fellowship in the group of Dennis Bray at the University of Cambridge, he modeled the molecular networks underlying bacterial chemotaxis. Le Novère then became involved in the development standards to share mathematical models such as SBML, of which he would later become editor.
In 2003, Le Novère built a research group at the European Bioinformatics Institute (EMBL-EBI). The group studied the signaling pathways underlying synaptic plasticity, in particular the allosteric calcium sensors. In parallel, his group coordinated the development of a consistent set of standards in systems biology, including the graphical notation SBGN, the guidelines MIRIAM and MIASE, the languages SED-ML and PharmML, and ontologies such as the Systems Biology Ontology. He also created BioModels Database and the Identifiers.org URIs.
Le Novère moved his group to the Babraham Institute in 2012.
He is currently associate editor of the journals BMC Systems Biology and NPJ Systems Biology and Applications.