Species Human Entrez 145957 | Human Mouse Ensembl ENSG00000169752 | |
Aliases NRG4, HRG4, neuregulin 4 External IDs MGI: 1933833 HomoloGene: 12921 GeneCards: NRG4 | ||
Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.
Contents
Function
The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation.
Clinical significance
Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.
References
Neuregulin 4 Wikipedia(Text) CC BY-SA