Naval Medical Research Unit Four (NAMRU-4) was a research laboratory of the US Navy which was commissioned 31 May 1946 at the Naval Hospital in Dublin, Georgia as the Mcintire Research Unit for Rheumatic Fever, which was named for the Surgeon General of the United States Navy Ross T. Mcintire. Initial staffing was 4 physicians, 4 laboratory technicians and 4 laboratory helpers under the command of LCDR John R. Seal. Eighteen months after commissioning the Navy transferred Dublin Naval Hospital to the Veterans Affairs system and the Secretary of the Navy re-established NAMRU-4 at Great Lakes Naval Base on the grounds of the Naval Hospital to study acute respiratory diseases in military personnel with a focus on their prevention. Lieutenant Commander Seal remained the Officer in Charge. The location at Great Lakes made it ideal as this was a large recruit training command with members arriving from all over the United States and being housed in military barracks and therefore would be expected to experience outbreaks of respiratory illness periodically. Diseases studied included:
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In 1954 NAMRU-4 would be the first microbiology lab to ever isolate influenza virus in tissue culture. In the same year they would be the first lab to ever identify influenza B virus. NAMRU-4 was disestablished in 1974.