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Nariman Mehta

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Citizenship
  
United States

Role
  
Organic Chemist

Name
  
Nariman Mehta


Spouse
  
Barbara DeShane

Nationality
  
United States

Fields
  
Organic chemistry

Nariman Mehta

Born
  
April 20, 1920 Bombay, India (
1920-04-20
)

Institutions
  
Seagram, GlaxoSmithKline

Alma mater
  
St. Xavier's College, Mumbai, University of Kansas

Known for
  
Synthesis of antidepressant drug Bupropion (marketed as Wellbutrin)

Died
  
August 22, 2014, Burlington, North Carolina, United States

Education
  
University of Kansas, St. Xavier's College-Autonomous, Mumbai

Nariman Bomanshaw Mehta (April 8, 1920 – August 22, 2014) was an Indian-born American organic chemist and pharmacologist who designed, synthesized, and patented the organic compound Bupropion, marketed under the name Wellbutrin as an antidepressant and smoking cessation aid.

Contents

Early life and education

Mehta was born in Bombay, India into a Parsi Zoroastrian family. He attended St. Xavier's College in Bombay, from where he received Bachelor of Science degrees in chemistry and physics and Bachelor of Arts degrees in English and economics, and a Master of Science degree. In 1939, he and fellow student Kaikhosrov D. Irani, later a noted academic in his own right, wrote and published the book “Textbook of Theoretical and Practical Physics”.

Mehta won a Tata Scholarship and received a grant from Wendell Willkie. In 1947 Mehta went to the United States, where he earned a PhD in chemistry from The University of Kansas.

He had two daughters and a son.

Career

Seagram invited Mehta to the United States as a trainee in their research lab where he learnt about fermentation and distillation. During his time at Seagram, Mehta studied the antibiotic Penicillin. While teaching chemistry at Central State University, Wilberforce, Ohio, Mehta joined the pharmaceutical company Burroughs Wellcome, Inc., now GlaxoSmithKline, where he worked on potential neuropsychopharmacological drugs and designed, synthesized, and patented (in 1969) the compound Bupropion (BW 323U66) that was approved for use as an antidepressant in 1985 and sold under the trade name Wellbutrin. Another application of the drug was as a smoking cessation aid.

Selected publications

  • Mehta, N B (1983), "The Chemistry of Bupropion", The Journal of Clinical Psychiatry (published May 1983), 44 (5), pp. 56–9, PMID 6406464 
  • David L. Musso; Nariman B. Mehta; Francis E. Soroko; Robert M. Ferris; Elizabeth B. Hollingsworth; Bernard T. Kenney (2004), "Synthesis and evaluation of the antidepressant activity of the enantiomers of bupropion", Chirality, Chirality (published 2004-09-21), 5 (7): 495–500, PMID 8240925, doi:10.1002/chir.530050704 
  • Mehta, Nariman B; Arthur P Phillips; Florence Fu Lui; Ronald E Brooks (1960), "Maleamic and citraconamic acids, methyl esters, and imides", The Journal of Organic Chemistry, 25 (6): 1012–1015, doi:10.1021/jo01076a038 
  • References

    Nariman Mehta Wikipedia