Type Fab fragment Target 5T4 CAS Number 676258-98-3 | Source Mouse ATC code none ChemSpider none | |
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What does naptumomab estafenatox mean
Naptumomab estafenatox (ABR-217620) is a drug being developed for the treatment of various types of cancer like non-small cell lung carcinoma and renal cell carcinoma.
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Mechanism of action
Chemically, it is a fusion protein consisting of the antigen-binding fragment (Fab) of a monoclonal antibody with the superantigen staphylococcal enterotoxin A (SEA/E-120, "estafenatox"). The Fab binds to 5T4, an antigen expressed by various tumor cells, and the superantigen induces an immune response by activating T lymphocytes.
References
Naptumomab estafenatox Wikipedia(Text) CC BY-SA