ATC code none PubChem CID 4416 ChemSpider 4263 Molar mass 425.562 g/mol | CAS Number 1845-11-0 IUPHAR/BPS 4263 UNII 4RIY10WM82 | |
 | ||
Medical vocabulary what does nafoxidine mean
Nafoxidine (INN) (developmental code names U-11,000A, NSC-70735), or nafoxidine hydrochloride (USAN), is a non-steroidal selective estrogen receptor modulator (SERM) or partial antiestrogen of the triphenylethylene group that was developed for the treatment of advanced breast cancer by Upjohn in the 1970s but was never marketed. It was developed at around the same time as tamoxifen and clomifene, which are also triphenylethylene derivatives. The drug was originally synthesized by the fertility control program at Upjohn as a postcoital contraceptive, but was subsequently repurposed for the treatment of breast cancer. Nafoxidine was assessed in clinical trials in the treatment of breast cancer and was found to be effective. However, it produced side effects including ichthyosis, partial hair loss, and phototoxicity of the skin in almost all patients, and this resulted in the discontinuation of its development.