Species Human Entrez 55270 | Human Mouse Ensembl ENSG00000136159 | |
Aliases NUDT15, MTH2, NUDT15D, nudix hydrolase 15 External IDs MGI: 2443366 HomoloGene: 10109 GeneCards: NUDT15 | ||
Gene music using protein sequence of nudt15 nudix nucleoside diphosphate linked moiety x type mo
Nudix hydrolase 15 is a protein that in humans is encoded by the NUDT15 gene.
Contents
Function
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.
References
NUDT15 Wikipedia(Text) CC BY-SA