Entrez 55270 | Ensembl ENSG00000136159 | |
Aliases NUDT15, MTH2, NUDT15D, nudix hydrolase 15 External IDs MGI: 2443366 HomoloGene: 10109 GeneCards: NUDT15 | ||
Gene music using protein sequence of nudt15 nudix nucleoside diphosphate linked moiety x type mo
Nudix hydrolase 15 is a protein that in humans is encoded by the NUDT15 gene.
Contents
- Gene music using protein sequence of nudt15 nudix nucleoside diphosphate linked moiety x type mo
- Function
- References
Function
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.
References
NUDT15 Wikipedia(Text) CC BY-SA