Species Human Entrez 9891 | Human Mouse Ensembl ENSG00000074590 | |
Aliases NUAK1, ARK5, NUAK family kinase 1 External IDs MGI: 1925226 HomoloGene: 8896 GeneCards: NUAK1 | ||
NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene.
Contents
Clinical significance
ARK5 is important in tumor malignancy and invasiveness.
Research findings
ARK5 is often overexpressed in multiple myeloma cell lines. ARK5 promotes tumor cell survival under regulation by Akt.
ARK5 increases MT1-MMP production. (MT1-MMP activates MMP-2 and MMP-9 which are involved in tumor metastasis.)
As a drug target
ON123300 (a CDK4 inhibitor), also inhibits ARK5 and reduces proliferation of multiple myeloma and mantle cell lymphoma cell lines.
Interactions
NUAK1 has been shown to interact with USP9X and Ubiquitin C.
References
NUAK1 Wikipedia(Text) CC BY-SA