Species Human Entrez 4885 | Human Mouse Ensembl ENSG00000106236 | |
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Aliases NPTX2, NARP, NP-II, NP2, neuronal pentraxin 2 External IDs MGI: 1858209 HomoloGene: 1892 GeneCards: NPTX2 | ||
Neuronal pentraxin-2 is a protein that in humans is encoded by the NPTX2 gene.
Contents
Function
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells.
Clinical significance
Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.
References
NPTX2 Wikipedia(Text) CC BY-SA