External IDs GeneCards: NEAT1 Human Mouse Ensembl ENSG00000245532 | Species Human Entrez 283131 | |
Aliases NEAT1, LINC00084, NCRNA00084, TncRNA, VINC, nuclear paraspeckle assembly transcript 1 (non-protein coding) | ||
Nuclear Enriched Abundant Transcript 1 (NEAT1) is a ~3.2 kb novel nuclear long non-coding RNA (RIKEN cDNA 2310043N10Rik). It is also known as Virus Inducible NonCoding RNA (VINC) or MEN epsilon RNA. It is transcribed from the multiple endocrine neoplasia locus.
Expression of NEAT1 is induced in mouse brains during infection by Japanese encephalitis virus and rabies virus. NEAT1 is constitutively expressed in a number of non-neuronal tissues and cell lines.
NEAT1 localizes to specific nuclear structures called paraspeckles. NEAT1 RNA interacts with a paraspeckle protein known as P54nrb or NONO and it is essential for paraspeckle formation. Some studies demonstrate that NEAT1 RNA is essential for the formation and maintenance of paraspeckles. Thus, this novel noncoding RNA appears to have an important structural role in the nuclear paraspeckles.