Species Human Entrez 81565 | Human Mouse Ensembl ENSG00000166579 | |
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Aliases NDEL1, EOPA, MITAP1, NDE1L1, NDE2, NUDEL, nudE neurodevelopment protein 1 like 1 External IDs MGI: 1932915 HomoloGene: 32567 GeneCards: NDEL1 | ||
Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.
This gene encodes a thiol-activated oligopeptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Interactions
NDEL1 has been shown to interact with Cyclin-dependent kinase 5, YWHAE, PAFAH1B1 and DISC1.
References
NDEL1 Wikipedia(Text) CC BY-SA