Murtha is a surname. Notable people with the surname include:
Andrew Murtha (born 1965), an Australian speed skater
John Murtha (1932–2010), a member of the United States Congress
John Garvan Murtha (born 1941), a United States federal judge
John Murtha (Wisconsin politician) (born 1951), a Wisconsin state assemblyman
Lydon Murtha (born 1985), an American football player
William H. Murtha (1841–1891), a merchant and New York politician