Professor Sir Munir Pirmohamed is a clinical pharmacologist, geneticist and the NHS Chair of Pharmacogenetics.
Munir Pirmohamed studied Medicine at the University of Liverpool from 1980 to 1985, Professor Pirmohamed then went on to study a PhD in Pharmacology in 1993, and began working as a Consultant Physician at the Royal Liverpool University Hospital in 1996. Professor Pirmohamed gained the position of Personal Chair in Clinical Pharmacology at The University of Liverpool in 2001, and went on to become the NHS Chair of Pharmacogenetics in 2007. Professor Pirmohamed is a member of the Commission on Human Medicines and Chair of its Pharmacovigilance Expert Advisory Group, in addition to the role of Deputy Director for the MRC Centre for Drug Safety Sciences in Liverpool. Alongside these responsibilities Professor Pirmohamed also sits on the advisory board for precision medicine company Geneix.
Pharmacogenetics and drug safety are the main areas of Professor Pirmohamed's research. With a particular focus on adverse drug reactions, their role in improving prescription choices and the development of genetic tests for personalised medicine.
Professor Pirmohamed has received the William Withering Medal from the Royal College of Physicians and the IPIT award for Public Service from the University of North Carolina in the US. Awarded a knighthood in Queen's birthday honors in June 2015 for services to Medicine.
British Medical AssociationAssociation of PhysiciansMedical Council on AlcoholMedical Research SocietyFellowship of Postgraduate MedicineProfessor Pirmohamed has been awarded funding from The UK Department of Health, NIHR, MRC, Wellcome Trust, Wolfson Foundation, and the EU FP7 programme funds .
Metabolism and bioactivation of clozapine by human liver in vitroNeutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosisInduction of metabolism-dependent and -independent neutrophil apoptosis by clozapine.Anticipating, investigating and managing the adverse effects of drugsTNF-alpha promoter region gene polymorphisms in carbamazepine-hypersensitive patientsAre chemically reactive metabolites responsible for adverse reactions to drugs?TNF-alpha promoter region gene polymorphisms in HIV-positive subjects with lipodystrophyBioactivation of clozapine by murine cardiac tissue in vivo and in vitroIntracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytesA method for the rapid depletion of albumin and immunoglobulin from human plasmaActive Transport Of Imatinib Into And Out Of Cells: Implications For Drug ResistanceWhole blood cultures from renal transplant patients stimulated ex-vivo show that the effects of cyclosporin on lymphocyte proliferation are related to P-glycoprotein expressionActive transport of imatinib into and out of cells: implications for drug resistanceCost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivityWhole blood cultures from renal transplant patients stimulated ex-vivo show that the effects of cyclosporin on lymphocyte proliferation are related to P-glycoprotein expressionAdverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patientsThe role of metabolic activation in drug-induced hepatotoxicityRelationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liverCharacterization of the T-cell response in a patient with phenindione hypersensitivityCarbamazepine-induced acute liver failure as part of the DRESS syndromehOCT 1 and resistance to imatinibDrug presentation to T cellsCharacterization of the T-cell response in a patient with phenindione hypersensitivityAltered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitorsInvestigation of toxic metabolites during drug developmentAssessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine- and zidovudine-containing regimensHow do NHS general hospitals in England deal with patients with alcohol-related problems? A questionnaire surveyThe quality of information on monitoring for haematological adverse drug reactionsThe pharmacogenetics of HIV therapyClinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort studyInduction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elementsClinical practice. Antibiotic allergyPharmacogenetics in clinical practice: considerations for testingBeyond registration—measuring the public-health potential of new treatments for malaria in AfricaSystemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartanSerious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene clusterSulfamethoxazole and Its Metabolite Nitroso Sulfamethoxazole Stimulate Dendritic Cell Costimulatory SignalingWarfarin: almost 60 years old and still causing problemsExon resequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistanceActivation of T-cells by carbamazepine and carbamazepine metabolitesThe future prospects of pharmacogenetics in oral anticoagulation therapyGenetic factors in the predisposition to drug-induced hypersensitivity reactionsThe HLA B locus in Caucasians patients with carbamazepine hypersensitivityAdverse drug reactions in hospital in-patients: A pilot studyDrug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitisGeneration and characterization of antigen-specific CD4(+), CD8(+), and CD4(+)CD8(+) T-cell clones from patients with carbamazopine hypersensitivityHerbal medicines and acute medical emergency admissions to hospitalMolecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicityImmunological principles of T-cell-mediated adverse drug reactions in skinFolate Augmentation of Treatment - Evaluation for Depression (FolATED): protocol of a randomised controlled trialSulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signalingGenetics of epilepsy: epilepsy research foundation workshop reportTacrine-induced liver damage: an analysis of 19 candidate genes
