Muller is a surname. Notable people with the surname include:
Albert A. Muller (fl. 1820's), South Carolina poet (see Wilson, James Grant; Fiske, John, eds. (1900). "Muller, Albert A.". Appletons' Cyclopædia of American Biography. New York: D. Appleton. )
Bauke Muller (born 1962), Dutch bridge player
Bill Muller (1965–2007), U.S. journalist
Bobby Muller (born 1946), Vietnam veteran
Carl Muller (born 1935), Sri Lankan Burgher writer, poet, and journalist
Charles Muller (born 1953), translator
Derek Muller (born 1982), science communicator
Dominique Muller (born 1949), French writer
Edouard Muller (1823-1876), Swiss-French painter
Édouard Muller (1919-1997), French road racing cyclist
Émile Muller (1915-1988), French politician
Franck Muller (born 1958), Swiss watchmaker
François Muller (1764–1808), French general of the French Revolutionary Wars
Frank Muller (1951–2008), Dutch audio book narrator and actor
Franz Muller (died 1864), German tailor, first to commit murder on a British train
Frederick Muller (1861–1946), American Medal of Honor recipient
Gary Muller (born 1964), South African tennis player
Germain Muller (1923-1994), French playwright, actor, poet, humourist, politician
Hendrik Pieter Nicolaas Muller (1859–1941), Dutch businessman, world traveler, publicist, diplomat and philanthropist
Henry J. Muller (born 1917), American brigadier general
Herbert J. Muller (1905–1980), American historian, academic, government official and author
Hermann Joseph Muller (1890–1967), U.S. geneticist (Muller's ratchet) and educator
Jacques Muller (1954-), French politician
Jacques Léonard Muller (1749–1824), French army commander of the French Revolutionary Wars
Jean Muller (1925–2005), French structural engineer
Jim Muller, co-founder of Voice of the Faithful
Judy Muller, American journalist
Kirk Muller (born 1966), Canadian hockey player
Lucien Muller (born 1934), former French midfielder footballer and manager
Mancow Muller (born 1966), American radio and television personality
Marcia Muller (born 1944), American mystery writer
Otto Friedrich Müller (1730–1784), Danish naturalist
Pieter Muller, South African rugby player
Richard A. Muller (born 1944, physicist), University of California, Berkeley
Robert Muller (1923–2010), United Nations employee
Romeo Muller (1928–1992), American actor and writer
Scott Muller (born 1970), Panamanian canoer
Scott Muller (born 1971), Australian cricketer
Sophie Muller (born 1964), British music video director
Steven Muller (born 1927), former President of Johns Hopkins University
Victor Muller (born 1959), Dutch entrepreneur
Yvan Muller (born 1969), French auto racing driver
Fictional characters:
Caroline "Cathy" Muller, fictional character created by Tom Clancy, wife of Jack Ryan
Rudolfine Muller, a character from Strike Witches
Jake Muller, Albert Wesker's illegitimate son and protagonist of the video game Resident Evil 6