Species Human Entrez 4488 | Human Mouse Ensembl ENSG00000120149 | |
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Aliases MSX2, CRS2, FPP, HOX8, MSH, PFM, PFM1, Msh homeobox 2 External IDs MGI: 97169 HomoloGene: 1837 GeneCards: MSX2 | ||
Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene.
Contents
Function
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.
Interactions
Msh homeobox 2 has been shown to interact with DLX5, DLX2 and MSX1.
References
Msh homeobox 2 Wikipedia(Text) CC BY-SA