Harman Patil (Editor)

MoRFs

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Molecular Recognition Features (MoRFs) are small (10-70 residues) intrinsically disordered regions in proteins that undergo a disorder-to-order transition upon binding to their partners. MoRFs are implicated in protein-protein interactions, which serve as the initial step in molecular recognition. MoRFs are disordered prior binding to their partners, whereas they form a common 3D structure after interacting with their partners.

Contents

Amino Acid composition

Their amino acid composition is very interesting. They look like disordered proteins, but they have some characteristics of ordered proteins.

Categorization

MoRFs can be separated in 4 categories according to the shape they form once bound to their partners.

The categories are:

  • α-MoRFs (when they form alpha-helixes)
  • β-MoRFs (when they form beta-sheets)
  • irregular-MoRFs (when they don't form any shape)
  • complex-MoRFs (combination of the above categories)

    • MoRFs Predictors

    MoRFPred ANCHOR MoRFchibi SYSTEM

    Databases

    mpMoRFsDB

    References

    MoRFs Wikipedia
    (Text) CC BY-SA